University of Angers introduces a monitoring electrochemical sensor box enabling low-cost, near real-time quantitative assessment of non-degradable and persistent chemicals such as pharmaceuticals, nitrites, plastic additives and Perfluoroalkyl substances (PFAS) in sweet water. Unlike other solutions on the market, UA’s sensor implements electrodes modified with molecularly imprinted polymers (MIPs) and gold nanoparticles to achieve higher selectivity and sensitivity to organic micropollutants. Combined with the on-site measurement capability and option to detect multiple contaminants simultaneously, the sensor is a steppingstone in the Common Implementation Strategy (CIS) of the Water Framework Directive (WFD) towards improved water quality surveillance and decision-making. The wide applicability of the sensor has been proven during the iMERMAID’s use case implementations at diverse wastewater treatment plants. The sensors demonstrated sensibility and selectivity far beyond limits required by national laws.